Shradha Prabhulkar, Rudolph Piatyszek, John R. Cirrito, Ze-Zhi Wu and Chen-Zhong Li Microbiosensor for Alzheimer’s disease diagnostics: detection of amyloid beta biomarkers Journal of Neurochemistry 122
Amyloid-β (Aβ) peptide accumulates in Alzheimer’s disease patients and is believed to precipitate disease onset. We developed an electrical immuno microsensor for highly sensitive and specific detection of different isoforms of Aβ. The label-free detection is based on quantitatively measuring redox signals of Aβ using a carbon fiber microelectrode array. Real-time detection capabilities and miniature size of sensor may allow for clinical diagnostic and potential in vivo animal study.
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