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Lidia García-Bonilla, Mireia Campos, Dolors Giralt, David Salat, Pilar Chacón, Mar Hernández-Guillamon, Anna Rosell and Joan Montaner Evidence for the efficacy of statins in animal stroke models: a meta-analysis Journal of Neurochemistry 122

Version of Record online: 21 MAY 2012 | DOI: 10.1111/j.1471-4159.2012.07773.x

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Statins for acute stroke: Pooled data from the bench gives clues for clinical trials design. Although the protective effect of statins on experimental stroke is not novel, a peer evaluation is needed to provide faithful translation into the clinics. This systematic review and meta-analysis supports the evidence of statin benefit to reduce infarct growth and improve neurological outcome in experimental stroke. Moreover, the analysis establishes the main factors influencing statin neuroprotective effect, such as type of statin, routes and timing of administration that might be used in clinical trials.

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