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Priit Pruunsild and Tõnis Timmusk Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression Journal of Neurochemistry 123

Version of Record online: 27 JUN 2012 | DOI: 10.1111/j.1471-4159.2012.07796.x

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KCNIP3/KChIP3 (voltage-dependent K+ channel interacting protein 3), alias Calsenilin and DREAM (downstream regulatory element antagonist modulator), is a multifunctional protein that modulates A-type potassium channels, affects processing of amyloid precursor protein and regulates transcription. This study was performed in order to assess the potential of KCNIP/Calsenilin/DREAM/KChIP family proteins to fulfill their functions in different cell compartments. We found that different KCNIP isoforms have distinct subcellular localization in neuronal cells and although some of the KCNIP protein isoforms are localized to the nuclei when over-expressed, they do not participate in CRE-dependent gene expression regulation and are not modulating the transcriptional activity of CREB family proteins in cultured cortical neurons.

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