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Shu-Qin Yao, Zheng-Zheng Li, Qing-Yuan Huang, Fang Li, Zhao-Wei Wang, Elisabete Augusto, Jin-Cai He, Xiao-Tong Wang, Jiang-Fan Chen and Rong-Yuan Zheng Genetic inactivation of the adenosine A2A receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis Journal of Neurochemistry 123

Version of Record online: 23 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07807.x

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The role of the adenosine A2A receptor (A2AR) in development of multiple sclerosis pathology was critically evaluated in EAE model using the A2AR knockout mice. A2AR knockout exacerbates EAE-induced demyelination, axonal injury, neurobehavioral deficits, and inflammatory responses. The A2AR represents an important neuroprotective mechanism and therapeutic target to modify multiple sclerosis pathology.

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