Shu-Qin Yao, Zheng-Zheng Li, Qing-Yuan Huang, Fang Li, Zhao-Wei Wang, Elisabete Augusto, Jin-Cai He, Xiao-Tong Wang, Jiang-Fan Chen and Rong-Yuan Zheng Genetic inactivation of the adenosine A2A receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis Journal of Neurochemistry 123
The role of the adenosine A2A receptor (A2AR) in development of multiple sclerosis pathology was critically evaluated in EAE model using the A2AR knockout mice. A2AR knockout exacerbates EAE-induced demyelination, axonal injury, neurobehavioral deficits, and inflammatory responses. The A2AR represents an important neuroprotective mechanism and therapeutic target to modify multiple sclerosis pathology.
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