E-mail

E-mail a Wiley Online Library Link

Nagendran Muthusamy, Victor Faundez and Clare Bergson Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes Journal of Neurochemistry 123

Article first published online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07814.x

Thumbnail image of graphical abstract

Calcyon regulates targeting of AP-3 cargoes Calcyon, a neural enriched mammalian specific protein implicated in clathrin-mediated endocytosis, contains canonical tyrosine type motifs for binding adaptor protein (AP) μ subunits. We found that targeted deletion of the calcyon gene in mice impacts the subcellular distribution of AP-3 and the localization of AP-3 cargoes. Thus, by directly interacting with AP μ subunits, calcyon regulates targeting of AP-3 cargoes in brain.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH