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Nagendran Muthusamy, Victor Faundez and Clare Bergson Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes Journal of Neurochemistry 123

Article first published online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07814.x

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Calcyon regulates targeting of AP-3 cargoes Calcyon, a neural enriched mammalian specific protein implicated in clathrin-mediated endocytosis, contains canonical tyrosine type motifs for binding adaptor protein (AP) μ subunits. We found that targeted deletion of the calcyon gene in mice impacts the subcellular distribution of AP-3 and the localization of AP-3 cargoes. Thus, by directly interacting with AP μ subunits, calcyon regulates targeting of AP-3 cargoes in brain.

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