Sara Cipriani, Cody A. Desjardins, Thomas C. Burdett, Yuehang Xu, Kui Xu and Michael A. Schwarzschild Protection of dopaminergic cells by urate requires its accumulation in astrocytes Journal of Neurochemistry 123
Article first published online: 22 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07820.x
Astroglial urate protects dopaminergic cells. Urate is a potent antioxidant and an inverse risk factor for Parkinson’s disease (PD). We showed that urate protects dopaminergic cells against oxidative stress in vitro. This protection depends on urate accumulation in astrocytes where it appears to trigger protective factor release. The findings suggest astrocytic urate elevation as a candidate neuroprotective strategy and novel pharmacological target for PD.
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