Sophie Schumm, Claude Sebban, Charles Cohen-Salmon, Jacques Callebert, Jean-Marie Launay, Jean-Louis Golmard, Lydie Boussicault, Isabelle Petropoulos, Audrey Hild, Estelle Rousselet, Annick Prigent, Bertrand Friguet, Jean Mariani and Etienne C. Hirsch Aging of the dopaminergic system and motor behavior in mice intoxicated with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Journal of Neurochemistry 122
Article first published online: 11 JUL 2012 | DOI: 10.1111/j.1471-4159.2012.07837.x
Aging is does not exacerbate Parkinson’s disease in miceBackground: The most important risk factor for Parkinson’s disease is aging but so far the effect of age on degeneration has not been studied in animal models. Findings: The study shows that aging does not exacerbate degeneration or symptoms in mice intoxicated by the parkinsonian toxin MPTP. Conclusions: These findings do not support the notion that PD develops with age after MPTP intoxication. Photographs of sections of the mesencephalon at 3 months in control mice and MPTP-intoxicated mice, respectively, (a–b) and 21 months (c–d). Evolution with age of dopaminergic and cresyl violet cell count (e,f) Semi-circle delimits SNpc and arrow shows SNpr; scale bar = 240 μm (a–f). Data are presented as mean ± SEM; *p < 0.05.
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