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Sade Spencer, Melissa I. Torres-Altoro, Edgardo Falcon, Rachel Arey, Marian Marvin, Matthew Goldberg, James A. Bibb and Colleen A. McClung A mutation in CLOCK leads to altered dopamine receptor function Journal of Neurochemistry 123

Version of Record online: 27 JUL 2012 | DOI: 10.1111/j.1471-4159.2012.07857.x

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Manic-like behavior may be because of altered dopaminergic transmission Why was this study performed? We wanted to gain a better understanding of the molecular and cellular changes that underlie bipolar disorder using a mouse model of mania (Clock mutant mice). What was the most relevant novel finding? Manic-like behavior in the Clock mutant mice is associated with increased dopamine and a shift in dopamine receptor function. Why is this finding important? If we can understand the molecular changes that lead to bipolar disorder then we can develop more targeted treatments for this disease in the future. In sum: Mice with a mutation that leads to manic-like behavior have abnormal dopamine signaling because of altered dopamine release and turnover, as well as altered dopamine receptor function. These changes in dopaminergic transmission likely underlie key components of their abnormal behavior. Future studies can use this knowledge to target this system for the development of novel therapies for bipolar disorder.

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