Margaret J. Ochocinska, Estela M. Muñoz, Shobi Veleri, Joan L. Weller, Steven L. Coon, Nikita Pozdeyev, P. Michael Iuvone, Sandra Goebbels, Takahisa Furukawa and David C. Klein NeuroD1 is required for survival of photoreceptors but not pinealocytes: Results from targeted gene deletion studies Journal of Neurochemistry 123
Article first published online: 16 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07870.x
‘New light on NeuroD1 and vision’1) This study was performed to investigate the post-natal role of the developmental transcription factor NeuroD1 in the retina and pineal gland. 2) The most relevant novel finding in our article is the identification of retinal and pineal transcripts that are affected by the NeuroD1 deletion and that NeuroD1 is required for proper post-natal survival and physiological function of the retinal photoreceptors. 3) This finding is important as it demonstrates the persistent role of developmental regulators throughout post-natal life and identifies new downstream targets of NeuroD1 that are important for photoreceptor homeostasis in the vertebrate retina.
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