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Parmvir K. Bahia, Victoria Pugh, Kimberley Hoyland, Victoria Hensley, Marcus Rattray and Robert J. Williams Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity Journal of Neurochemistry 123

Article first published online: 16 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07877.x

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Neuroprotective potential of the dietary phenolic antioxidant tBHQ through inhibition of FoxO3aWe wished to test whether phenolic antioxidants such as the FDA-approved food preservative tBHQ could oppose activation of FoxO3a-induced death responses in cortical and motor neurones. tBHQ inhibited NMDA-induced nuclear translocation of FoxO3a, prevented NMDA-induced up-regulation of FoxO-mediated transcriptional activity, blocked caspase-3 activation and protected neurones from excitotoxicity. Collectively, this supports the concept that tBHQ and structurally similar antioxidants have potential neuroprotective utility in neurodegeneration, particularly in those conditions linking FoxO activation to oxidative stress and excitotoxic neuronal cell death.

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