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Bryan A. Haines, Darcy A. Davis, Artem Zykovich, Botao Peng, Rammohan Rao, Sean D. Mooney, Kunlin Jin and David A. Greenberg Comparative protein interactomics of neuroglobin and myoglobin Journal of Neurochemistry 123

Article first published online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07881.x

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Neuroglobin and Myoglobin InteractomesTo explore mechanisms of neuroglobin-mediated cytoprotection from hypoxia and ischemia, we investigated protein–protein interactions of neuroglobin and myoglobin in normoxic and hypoxic cells. Some interactors were unique to neuroglobin or myoglobin, or to normoxia or hypoxia, whereas others were shared; neuroglobin interactors included anti-oxidative and anti-apoptotic proteins, as well as proteins implicated in neurodegenerative diseases. Protein–protein interactions of neuroglobin may be important for its neuroprotective effects.

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