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Beáta Lontay, Balázs Pál, Zoltán Serfőző, Áron Kőszeghy, Géza Szücs, Zoltán Rusznák and Ferenc Erdődi Protein phosphatase-1M and Rho-kinase affect exocytosis from cortical synaptosomes and influence neurotransmission at a glutamatergic giant synapse of the rat auditory system Journal of Neurochemistry 123

Version of Record online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07882.x

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Protein phosphatase-1M (PP1M) and RhoA-activated kinase (ROK) are present pre- and post-synaptically in both cortical synaptosomes and in a glutamatergic giant synapse of the rat auditory system. PP1 inhibition by tautomycetin (TMC) suppresses, whereas ROK inhibition by Y27632 increases neurotransmitter release. We suggest that both PP1M and ROK influence synaptic transmission by changing the phosphorylation status of several pre- and post-synaptic proteins.

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