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Xiaoying Bi, Yanbo Zhang, Bin Yan, Shaokuan Fang, Jue He, Dai Zhang, Zhijun Zhang, Jiming Kong, Qingrong Tan and Xin-Min Li Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice Journal of Neurochemistry 123

Version of Record online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07883.x

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Quetiapine prevents oligodendrocyte and myelin losses and promotes oligodendrocyte maturation in the hippocampus of global cerebral ischemia mice The anti-psychotic quetiapine is used as an augment in vascular depression treatment with unknown mechanisms. This study demonstrated that quetiapine pre-treatment reduced hippocampal myelin breakdown and oligodendrocyte losses in a mouse model of vascular depression, and enhanced oligodendrocyte maturation in recovery. The results suggest the new feature of quetiapine that may be an important contributor in treating vascular depression.

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