Kristen Browne, Wenyan Wang, Rachel Q. Liu, Matthew Piva and Timothy P. O’Connor Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue Journal of Neurochemistry 123
Neural growth cones respond to a number of directional guidance cues, including both transmembrane and secreted Semaphorin proteins. We describe the first evidence that transmembrane Semaphorin5B is proteolytically processed by metalloproteases to release a repulsive neural guidance cue. This work presents a novel mechanism whereby transmembrane Semaphorins may extend their repulsive range via modulation of local metalloprotease expression and activity.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf