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Kristen Browne, Wenyan Wang, Rachel Q. Liu, Matthew Piva and Timothy P. O’Connor Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue Journal of Neurochemistry 123

Version of Record online: 14 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07885.x

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Neural growth cones respond to a number of directional guidance cues, including both transmembrane and secreted Semaphorin proteins. We describe the first evidence that transmembrane Semaphorin5B is proteolytically processed by metalloproteases to release a repulsive neural guidance cue. This work presents a novel mechanism whereby transmembrane Semaphorins may extend their repulsive range via modulation of local metalloprotease expression and activity.

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