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Rodrigo Herrera-Molina, Betsi Flores, Juan A. Orellana and Rommy von Bernhardi Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways Journal of Neurochemistry 123

Article first published online: 22 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07887.x

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TGFβ1 modulates glial cell inflammatory activationGlial cells activation profile determines neuronal functional outcome and survival. TGFβ1 participates in the modulation of glia-mediated cytotoxicity and radicals production. We found that TGFβ1 and IFNγ show reciprocal regulation of MAPKs and STAT1, modulating IFNγ-induced superoxide and NO production by glial cells. MAPK phosphatase MKP1 was critical for the inhibitory effect of TGFβ1. We identified a potential therapeutic target to modulate glial activation in neurodegenerative diseases

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