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M. Rosario Sepúlveda, Frank Wuytack and Ana M. Mata High levels of Mn2+ inhibit secretory pathway Ca2+/Mn2+-ATPase (SPCA) activity and cause Golgi fragmentation in neurons and glia Journal of Neurochemistry 123

Article first published online: 3 SEP 2012 | DOI: 10.1111/j.1471-4159.2012.07888.x

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Manganese is an essential trace element, but in excess can be neurotoxic. Mn2+ overload compromises survival of neurons and glia in primary cultures specifically affecting Golgi organization. Golgi houses the Ca2+/Mn2+-ATPase SPCA, whose activity is inhibited by high Mn2+ levels. Glia is more resistant to Mn2+ toxicity than neurons and provides some protection against neurodegeneration. Furthermore, Mn2+ effects could be reversed upon Mn2+ removal.

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