Alejandro Bustamante, Dolors Giralt, Lidia Garcia-Bonilla, Mireia Campos, Anna Rosell and Joan Montaner Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial Journal of Neurochemistry 123
Citicoline meta-analysis in experimental stroke Translation of neuroprotective drugs into clinical practice has repeatedly failed. The meta-analysis here conducted aimed to verify the described neuroprotective benefits of citicoline therapy on animal stroke models. Although these effects were verified, we found that STAIR criteria have not been fulfilled and we identified several factors that may be important for a better translation into clinical trials.
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