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Carla Nasca, Rosamaria Orlando, Moreno Marchiafava, Paolo Boldrini, Giuseppe Battaglia, Sergio Scaccianoce, Francesco Matrisciano, Anna Pittaluga and Ferdinando Nicoletti Exposure to predator odor and resulting anxiety enhances the expression of the α2δ subunit of voltage-sensitive calcium channels in the amygdala Journal of Neurochemistry 125

Version of Record online: 8 JAN 2013 | DOI: 10.1111/j.1471-4159.2012.07895.x

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Changes in α2δ subunit expression in anxiety modelThe α2δ subunit is the molecular target for pregabalin, which is used in humans for the treatment of anxiety disorders. We found that α2δ subunit was up-regulated in the amygdala in a mouse model of innate anxiety where pregabalin was proved to be effective. These findings suggest that pregabalin acts as ‘disease-dependent’ drug in the treatment of anxiety.

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