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Jon-Eric VanLeeuwen and Peter Penzes Long-term perturbation of spine plasticity results in distinct impairments of cognitive function Journal of Neurochemistry 123

Article first published online: 11 OCT 2012 | DOI: 10.1111/j.1471-4159.2012.07899.x

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Long-term perturbation of spine plasticity results in distinct impairments of cognitive function

Using genetically modified mice deficient in a central regulator of spine plasticity, we investigated the brain region-specific contribution of spine numbers to various cognitive functions. We found distinct cognitive functions display differential sensitivity to spine loss in the cortex and hippocampus. Our data support spines as neuronal structures important for cognition and suggest interplay between brain regions is critical for complex cognitive processing.

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