Sonya B. Dumanis, Amanda M. DiBattista, Matthew Miessau, Charbel E. H. Moussa and G. William Rebeck APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals Journal of Neurochemistry 124
Article first published online: 28 SEP 2012 | DOI: 10.1111/j.1471-4159.2012.07908.x
Using human APOE knock-in mice, we found that APOE genotype affected pre-synaptic components in normal brain. Specifically, APOE-ε4 TR mice had decreased glutaminase levels and increased levels of the vesicular glutamate transporter VGLUT1. Using high-frequency 13C/1H nuclear magnetic resonance spectroscopy, we found that APOE-ε4TR mice have decreased production of glutamate and increased levels of glutamine.
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