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Young Jin Lee and Ilia V. Baskakov The cellular form of the prion protein is involved in controlling cell cycle dynamics, self-renewal, and the fate of human embryonic stem cell differentiation Journal of Neurochemistry 124

Version of Record online: 3 SEP 2012 | DOI: 10.1111/j.1471-4159.2012.07913.x

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A diverse range of functions has been proposed for mammalian prion protein or PrPC. The current study illustrates that PrPC is involved in regulating cell cycle dynamics, self-renewal and determining the fate of human embryonic stem cells. This work suggests that PrPC is involved in key activities that dictate the status of embryonic stem cells.

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