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Lei Jiang, Misty D. Bechtel, Nadezhda A. Galeva, Todd D. Williams, Elias K. Michaelis and Mary L. Michaelis Decreases in plasma membrane Ca2+-ATPase in brain synaptic membrane rafts from aged rats Journal of Neurochemistry 123

Version of Record online: 11 OCT 2012 | DOI: 10.1111/j.1471-4159.2012.07918.x

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The aging synapse: Ca2+ pumps and rafts

Dysregulation of Ca2+ homeostasis is associated with brain aging and loss of membrane Ca2+ pumping activity is one contributor. We found the highest synaptic membrane Ca2+ pumping activity in the lipid rafts and the greatest loss with age in raft domains. Significant localization of the pump within rafts suggests the lipid environment may strongly influence its activity in aging brain.

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