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Catarina S. Pereira, Jessica A. Thompson and Karina B. Xavier AI-2-mediated signalling in bacteria FEMS Microbiology Reviews 37

Article first published online: 16 JUL 2012 | DOI: 10.1111/j.1574-6976.2012.00345.x

Since the discovery of autoinducer-2 (AI-2), the first interspecies communication molecule in bacteria, an explosion of research that characterizes this signal, the mechanisms for its synthesis, detection, and its physiological role, has been carried out; here we comprehensively review all aspects of this story, the current developments and the future possibilities for quorum quenching, and manipulation of bacterial behaviours through this single molecule.

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