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Gerrit J. Schut, Eric S. Boyd, John W. Peters and Michael W.W. Adams The modular respiratory complexes involved in hydrogen and sulfur metabolism by heterotrophic hyperthermophilic archaea and their evolutionary implications FEMS Microbiology Reviews 37

Article first published online: 12 JUL 2012 | DOI: 10.1111/j.1574-6976.2012.00346.x

The membrane-bound [NiFe]-hydrogenase of the hyperthermophilic archaea, which in some species is associated with modules that catalyze the oxidation of formate, carbon monoxide or NAD(P)H, evolves hydrogen gas and conserves energy in the form of an ion gradient thereby representing a simple respiratory system within a single complex that phylogenetic analyses show is ancestral to [NiFe]-hydrogenases in general and complex I of the aerobic respiratory chain.

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