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A. I. Musat, R. M. Agni, P. Y. Wai, J. D. Pirsch, D. F. Lorentzen, A. Powell, G. E. Leverson, J. M. Bellingham, L. A. Fernandez, D. P. Foley, J. D. Mezrich, A. M. D’Alessandro and M. R. Lucey The Significance of Donor-Specific HLA Antibodies in Rejection and Ductopenia Development in ABO Compatible Liver Transplantation American Journal of Transplantation 11

Version of Record online: 22 FEB 2011 | DOI: 10.1111/j.1600-6143.2010.03414.x

The detection of circulating donor-specific HLA antibodies in association with C4d tissue deposition in ABO-compatible liver allografts suggests that humoral alloreactivity is frequently intertwined with cellular mechanisms of rejection, and that it plays a role in bile duct injury and ductopenia development. See editorial by Knechtle on page 424.

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