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W. H. Kitchens, D. Haridas, M. E. Wagener, M. Song, A. D. Kirk, C. P. Larsen and M. L. Ford Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8+ Memory T Cells American Journal of Transplantation 12

Article first published online: 22 SEP 2011 | DOI: 10.1111/j.1600-6143.2011.03762.x

Using a transgenic mouse transplant system that models graft rejection by costimulation blockade-resistant donor-specific memory T cells, the authors demonstrate that immunosuppression regimens coupling costimulatory blockade with either LFA-1 or VLA-4 antagonism overcomes the “memory barrier” and significantly prolongs graft survival.

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