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X. Zhao, O. Boenisch, M. Yeung, B. Mfarrej, Sunmi Yang, L. A. Turka, M. H. Sayegh, J. Iacomini and X. Yuan Critical Role of Proinflammatory Cytokine IL-6 in Allograft Rejection and Tolerance American Journal of Transplantation 12

Version of Record online: 12 OCT 2011 | DOI: 10.1111/j.1600-6143.2011.03770.x

Using interleukin-6 knockout mice as cardiac transplantation recipients, the authors show that interleukin-6 deficiency cooperates with costimulatory blockade in promoting allograft acceptance, and the mechanism underlining this effect lies in the limitation of effector T cell expansion, promotion of Treg function and their distribution in the graft.

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