M. Tanemura, Y. Ohmura, T. Deguchi, T. Machida, R. Tsukamoto, H. Wada, S. Kobayashi, S. Marubashi, H. Eguchi, T. Ito, H. Nagano, M. Mori and Y. Doki Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo American Journal of Transplantation 12
Article first published online: 3 OCT 2011 | DOI: 10.1111/j.1600-6143.2011.03771.x
This study shows that the upregulation of autophagy mediated by rapamycin treatment results in a significant impairment of cell insulin function, which may contribute to islet graft dysfunction observed in islet recipients.
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