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MARIA-LUISA ALEGRE and JONATHAN S. BROMBERG LITERATURE Watch Implications for transplantation American Journal of Transplantation 12

Article first published online: 13 JAN 2012 | DOI: 10.1111/j.1600-6143.2011.03937.x

In recent years, insight into the role of unique immune molecules in preventing infections has been gleaned from the study of patients with recurrent single-agent infections, and the IL-17 pathway is gaining particular attention. This month, Maria-Luisa Alegre and Jonathan Bromberg discuss three recent papers that strongly link a defect in the IL-17 pathway to chronic mucocutaneous candidiasis, a condition thought to be controlled by the adaptive immune system, in contrast to the neutrophil requirement for prevention of invasive candidiasis.

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