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G. Frumento, Y. Zheng, G. Aubert, M. Raeiszadeh, P. M. Lansdorp, P. Moss, S. P. Lee and F. E. Chen Cord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy After TCR Gene Transfer to Confer EBV Specificity American Journal of Transplantation 13

Version of Record online: 27 SEP 2012 | DOI: 10.1111/j.1600-6143.2012.04286.x

Human umbilical cord blood T cells can be redirected by T cell receptor gene transduction to target Epstein–Barr virus epitopes, and when compared in vitro with adult T cells they demonstrate properties predictive of better in vivo proliferative capacity and effector function, suggesting that cord blood can be used as a third party source of T cells for immunotherapy of posttransplant lymphoproliferative disease.

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