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M. C. Lowe, I. R. Badell, A. P. Turner, P. W. Thompson, F. V. Leopardi, E. A. Strobert, C. P. Larsen and A. D. Kirk Belatacept and Sirolimus Prolong Nonhuman Primate Islet Allograft Survival: Adverse Consequences of Concomitant Alefacept Therapy American Journal of Transplantation 13

Version of Record online: 27 DEC 2012 | DOI: 10.1111/j.1600-6143.2012.04341.x

This study demonstrates that a therapy combining belatacept and sirolimus effectively prevents acute islet allograft rejection in rhesus monkeys without the need for steroids or calcineurin inhibitors, and that the addition of alefacept induction promotes cytomegalovirus reactivation and fails to improve survival. See related article by Lo et al (page 320).

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