D. J. Lo, D. J. Anderson, T. A. Weaver, F. Leopardi, M. Song, A. B. Farris, E. A. Strobert, J. Jenkins, N. A. Turgeon, A. K. Mehta, C. P. Larsen and A. D. Kirk Belatacept and Sirolimus Prolong Nonhuman Primate Renal Allograft Survival Without a Requirement for Memory T Cell Depletion American Journal of Transplantation 13
Version of Record online: 11 JAN 2013 | DOI: 10.1111/j.1600-6143.2012.04342.x
This study demonstrates that a therapy combining belatacept and sirolimus effectively prevents acute renal allograft rejection in rhesus monkeys, and that when these agents are optimally dosed, the addition of alefacept induction promotes cytomegalovirus reactivation and fails to improve survival. See related article by Lowe et al (page 312).
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