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Raija H. Tammi, Alberto G. Passi, Kirsi Rilla, Evgenia Karousou, Davide Vigetti, Katri Makkonen and Markku I. Tammi Transcriptional and post-translational regulation of hyaluronan synthesis The FEBS Journal 278

Version of Record online: 25 MAR 2011 | DOI: 10.1111/j.1742-4658.2011.08070.x

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Changes in the content, molecular mass and turnover rate of hyaluronan are crucial for cell proliferation, migration, and apoptosis, processes that control tissue remodeling during embryonic development, inflammation, injury and cancer. Here, transcriptional regulation of hyaluronan synthase (Has1-3), post-translational control of HAS activity and the supply of the UDP-sugar substrates of HAS are highlighted as regulators of hyaluronan synthesis.

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