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Kailash N. Pandey The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: Perspectives and paradigms FEBS Journal 278

Article first published online: 7 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08081.x

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Molecular approaches to delineate the functional roles of guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) gene (Npr1) in physiological and pathophysiological disease states including high blood pressure, cardiac hypertrophy, and congestive heart failure are described here. Comparative analyses of biochemical properties and physiological genomics of Npr1 gene should provide enormous potentials in understanding the biological functions of GC-A/NPRA signaling in hypertension and cardiovascular regulation at the molecular level.

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