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Kunio S. Misono, John S. Philo, Tsutomu Arakawa, Craig M. Ogata, Yue Qiu, Haruo Ogawa and Howard S. Young Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase FEBS Journal 278

Article first published online: 7 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08083.x

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Atrial natriuretic peptide plays a central role in cardiovascular homeostasis through their natriuretic, vasorelaxant, and anti-hypertrophic activities. Such activities are mediated by the guanylate cyclase-linked, single transmembrane segment receptor functioning as a homodimer. Studies have revealed the structural mechanisms of transmembrane signaling and possible chloride-dependent allosteric control of the receptor activity in the kidney.

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