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Akio Yamazaki, Fumio Hayashi, Isao Matsuura and Vladimir A. Bondarenko Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation The FEBS Journal 278

Version of Record online: 20 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08104.x

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Pαβγ slowly changes its conformation after cGMP binding, i.e., after formation of Pαβγ containing two cGMPs. Binding of Pγ accelerates the conformational change caused by cGMP, but does not add another change. Pαβγ changes its conformation during its inactivation and that the binding of cGMP and Pγ is crucial for this change.

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