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Yasuhiro Ishihara, Fumiaki Ito and Norio Shimamoto Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis FEBS Journal 278

Article first published online: 28 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08105.x

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We previously showed that BimEL was deeply involved in hepatocyte apoptosis under oxidative stress conditions. The Bim promoter region includes an AP-1 binding site, a FOXO binding site, and three myb binding sites. In this study, we found that a component of AP-1, c-Fos is critical for BimEL upregulation and apoptosis.

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