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Elisabetta Passera, Barbara Campanini, Franca Rossi, Valentina Casazza, Menico Rizzi, Roberto Pellicciari and Andrea Mozzarelli Human kynurenine aminotransferase II – reactivity with substrates and inhibitors The FEBS Journal 278

Version of Record online: 28 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08106.x

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Kynurenine aminotransferase (KAT) is a pyridoxal 5′-phosphate-dependent enzyme catalyzing the formation of kynurenic acid, an antagonist of excitatory receptors in the CNS. KATII is a potential drug target for the treatment of schizophrenia. KATII spectroscopy, transamination and β-lytic activity were characterized with substrate and substrate analogs using novel continuous and high-throughput assays.

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