Elisabetta Passera, Barbara Campanini, Franca Rossi, Valentina Casazza, Menico Rizzi, Roberto Pellicciari and Andrea Mozzarelli Human kynurenine aminotransferase II – reactivity with substrates and inhibitors The FEBS Journal 278
Kynurenine aminotransferase (KAT) is a pyridoxal 5′-phosphate-dependent enzyme catalyzing the formation of kynurenic acid, an antagonist of excitatory receptors in the CNS. KATII is a potential drug target for the treatment of schizophrenia. KATII spectroscopy, transamination and β-lytic activity were characterized with substrate and substrate analogs using novel continuous and high-throughput assays.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf