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Moumita Samanta, Mousumi Banerjee, Mathur R. N. Murthy, Hemalatha Balaram and Padmanabhan Balaram Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis – distal effects on dimer stability The FEBS Journal 278

Version of Record online: 28 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08110.x

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The role of the fully conserved Cys126 residue in triosephosphate isomerase is probed using the engineered mutants, C126S, C126A, C126V, C126M and C126T of the Plasmodium falciparum enzyme. The mutant enzymes exhibited diminished thermal stability at low concentration, suggesting that Cys126 contributes to dimer stability through a crucial network of interactions.

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