Christel Rothe Brinkmann, Christian Würtz Heegaard, Torben Ellebæk Petersen, Jens Christian Jensenius and Steffen Thiel The toxicity of bovine α-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells FEBS Journal 278
Article first published online: 28 APR 2011 | DOI: 10.1111/j.1742-4658.2011.08112.x
A complex between α-lactalbumin and oleic acid has been reported to be cytotoxic to cancer cells. We have prepared such complexes and tested the activity against cancer cell lines and non-cancer-derived primary cells. Interestingly, some primary cell types were more sensitive to treatment than cancer cell lines, and we found the activity to be mediated by the oleic acid.
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