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Aline H. da Silva Cruz, Matthias Brock, Patrícia F. Zambuzzi-Carvalho, Ludier K. Santos-Silva, Rogério F. Troian, Alfredo M. Góes, Célia M. de Almeida Soares and Maristela Pereira Phosphorylation is the major mechanism regulating isocitrate lyase activity in Paracoccidioides brasiliensis yeast cells The FEBS Journal 278

Version of Record online: 31 MAY 2011 | DOI: 10.1111/j.1742-4658.2011.08150.x

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Here, we investigated the transcriptional and post-translational regulation of the glyoxylate cycle key-enzyme isocitrate lyase (PbICL) in the human pathogenic fungus Paracoccidioides brasiliensis. Our results imply a novel regulation mechanism of the fungal glyoxylate cycle, which is independent of the transcriptional regulation, but controlled by post-translational modification

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