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Owen M. Woodward, Anna Köttgen and Michael Köttgen ABCG transporters and disease FEBS Journal 278

Article first published online: 13 JUN 2011 | DOI: 10.1111/j.1742-4658.2011.08171.x

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ABC transporters transport a broad array of substrates across membranes. The physiological substrate of many ABC transporters, however, has remained elusive. Here we review the role of ABCG transporters in disease focusing on the recent discovery of mutations in ABCG2 causing hyperuricemia and gout, which has led to the identification of urate as a physiological substrate for ABCG2.

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