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Timo Eichner and Sheena E. Radford Understanding the complex mechanisms of β2-microglobulin amyloid assembly FEBS Journal 278

Article first published online: 13 JUN 2011 | DOI: 10.1111/j.1742-4658.2011.08186.x

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This review focuses on recent advances in developing a molecular description of the folding and aggregation mechanisms of the human amyloidogenic protein β2-microglobulin (β2m) under physiologically-relevant conditions. In particular, the structural and dynamic properties of the non-native folding intermediate IT and its role in the initiation of fibrillation and the development of dialysis-related amyloidosis are discussed

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