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Hanna Willander, Erik Hermansson, Jan Johansson and Jenny Presto BRICHOS domain associated with lung fibrosis, dementia and cancer – a chaperone that prevents amyloid fibril formation? The FEBS Journal 278

Version of Record online: 5 JUL 2011 | DOI: 10.1111/j.1742-4658.2011.08209.x

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The BRICHOS domain is found in several protein families associated with dementia, amyloid, interstitial lung disease and cancer. BRICHOS domains from Bri2 and proSP-C efficiently prevent the amyloid β-peptide, associated with Alzheimer′s disease, from forming amyloid fibrils.We speculate that the BRICHOS domain can chaperone β-prone regions in precursor proteins and thereby prevent aggregation and amyloid formation

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