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Michael Landreh, Juan Astorga-Wells, Jan Johansson, Tomas Bergman and Hans Jörnvall New developments in protein structure–function analysis by MS and use of hydrogen–deuterium exchange microfluidics FEBS Journal 278

Article first published online: 5 JUL 2011 | DOI: 10.1111/j.1742-4658.2011.08215.x

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Mass spectrometry (MS) is a powerful tool in protein structure analysis. In this review, we summarize some of the recent developments and applications in gas phase fragmentation, ion mobility technology, chemical crosslinking and hydrogen/deuterium exchange (HDX) mass spectrometry. We also demonstrate the use of a microfluidic cell for on-line HDX-MS to monitor aggregation of the amyloid-β peptide 1-40

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