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Dashayini Mahalingam, Ling L. Tay, Wei H. Tan, Juin H. Chai and Xueying Wang Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts The FEBS Journal 278

Version of Record online: 6 SEP 2011 | DOI: 10.1111/j.1742-4658.2011.08290.x

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We identified that mutant template human telomerase RNAs (MT-hTers) induce double strand breaks (DSBs)-like damages following 53BP1 and γ-H2AX foci formation in telomerase-overexpressing IMR90 (IMR90 WThTERT) cells, but not in normal IMR90 cells under similar treatments. Western blot analysis showed that these effects were mediated via the TRF2-ATM pathway and p53 activation, ultimately leading to apoptosis plausibly following elevation of GADD45γ.

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