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Torleif Härd Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies FEBS Journal 278

Article first published online: 6 SEP 2011 | DOI: 10.1111/j.1742-4658.2011.08295.x

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Oligomeric aggregates of the amyloid β-protein (Aβ) have been shown to play a fundamental neurotoxic role in Alzheimer’s disease. However, research is complicated by the multitude of different interconverting aggregates that Aβ can form in vitro and in vivo, and by the inhomogeneity and instability of in vitro preparations. Here we review recent studies in which protein engineering, and in particular disulfide engineering, has been applied to stabilize different Aβ aggregates

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