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Andreas Cederlund, Gudmundur H. Gudmundsson and Birgitta Agerberth Antimicrobial peptides important in innate immunity The FEBS Journal 278

Version of Record online: 19 SEP 2011 | DOI: 10.1111/j.1742-4658.2011.08302.x

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Antimicrobial peptides (AMPs) can be considered as our own antibiotics. Through disruption of microbial cell membranes AMPs eliminate microorganisms and hence inhibit or prevent infections. They are also involved in regulating the composition of the microbiota. In this review the two major classes of mammalian AMPs, defensins and cathelicidins, are discussed with emphasis on their structures, functions and regulation

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