Rok Košir, Ursula Prosenc Zmrzljak, Tanja Bele, Jure Acimovic, Martina Perse, Gregor Majdic, Cornelia Prehn, Jerzy Adamski and Damjana Rozman Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland – involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1 FEBS Journal 279
Article first published online: 26 SEP 2011 | DOI: 10.1111/j.1742-4658.2011.08317.x
By applying cAMP responsive element modulator (Crem) knockout mice we evaluated how CREM isoforms contribute to circadian expression of steroidogenic Cyp51, 11a1, 17a1, 11b1, 11b2 and 21a1 in mouse adrenal glands. Most striking is the CREM dependent hypo-methylation of Cyp17a1 promoter at zeitgeber time 12 that resulted in higher Cyp17a1 mRNA and protein expression in the knockout adrenals.
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