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Mark Wehner, Simone Kunzelmann and Christian Herrmann The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis The FEBS Journal 279

Version of Record online: 30 NOV 2011 | DOI: 10.1111/j.1742-4658.2011.08415.x

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The GTPase activity of the human guanylate binding protein 1 (hGBP1) is regulated by dimerization of the GTP binding domains. This dimerization results in a concentration-dependent self-activation of GTP turnover. In this study we identify the guanine cap as the key regulator for dimerization and an intramolecular contact between switch I and the guanine cap which transmits the nucleotide state.

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