Mark Wehner, Simone Kunzelmann and Christian Herrmann The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis The FEBS Journal 279
The GTPase activity of the human guanylate binding protein 1 (hGBP1) is regulated by dimerization of the GTP binding domains. This dimerization results in a concentration-dependent self-activation of GTP turnover. In this study we identify the guanine cap as the key regulator for dimerization and an intramolecular contact between switch I and the guanine cap which transmits the nucleotide state.
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